BMJ8d
Diagnosis of osteoporosis in statin-treated patients is dose-dependent
Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to ...
BMJ10d
Psoriasis assessment tools in clinical trials
1 Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA 2 Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT, USA ...
BMJ9d
Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis
Objective Rheumatoid arthritis (RA) immunopathogenesis revolves around the presentation of poorly characterised self-peptides by human leucocyte antigen (HLA)-class II molecules on the surface of ...
BMJ5d
Transplacental passage of belimumab during pregnancy and follow-up of a child exposed in utero
A recent report from the Belimumab Pregnancy Registry (NCT01532310) analysed available data on the consequences of belimumab (BEL) use in pregnant women with systemic lupus erythematosus (SLE).1 ...
BMJ9d
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis
Correspondence to Dr Tristan Maerz, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA; tmaerz{at}med.umich.edu Objectives Synovium is acutely affected following joint ...
BMJ3d
AB0150 IMMATURE GRANULOCYTES LEVEL IS A POTENTIAL BIOMARKER IN PERIPHERAL ENTHESITIS
Background: Immature granulocytes (IG) level in peripheral blood is used as early sign of infection. On the other hand, IG could be elevated in other conditions like inflammatory or cancerous diseases ...
BMJ4d
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study
5 The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Objectives and methods With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were ...
BMJ9d
Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor α blockers in ankylosing spondylitis
Background: TNFα blockers have been shown to be highly efficacious in patients with active ankylosing spondylitis (AS). Objective: To identify parameters predicting the clinical response to TNF ...
BMJ5d
Factors associated with long-term cardiac dysfunction in neonatal lupus
Objectives Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality; however, there is minimal information on long-term outcomes of affected ...
BMJ9d
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis
1 Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands 2 Department of Rheumatology, Leiden University Medical Centre, Leiden, ...
BMJ12d
Implementation of recommendations in rheumatic and musculoskeletal diseases: considerations for development and uptake
A clinical guideline is a document with the aim of guiding decisions based on evidence regarding diagnosis, management and treatment in specific areas of healthcare. Specific to rheumatic and ...
BMJ8d
POS0980 ANALYSIS OF PRIMARY CARE CONSULTATION PATTERNS TO AID DIAGNOSIS OF AXIAL SPONDYLOARTHRITIS – AN EXPLORATORY CASE SERIES
2 Faculty of Health, Psychology and Social Care, Manchester Metropolitan University, Manchester, United Kingdom 3 Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United ...