While humans can escape the heat by seeking shade or shedding layers, plants remain rooted in place. So how do they survive ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

While humans can escape the heat by seeking shade or shedding layers, plants remain rooted in place. So how do they survive extreme heat? It's a ...

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

Spinal muscular atrophy is caused by homozygous mutation of SMN1. There are several potential approaches to tweaking SMN2 messenger RNA, to raise SMN protein levels to therapeutic levels. One such ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function. In most eukaryotic cells, two types of ...

The spliceosome and Group II introns are believed to share a common ancestor that was responsible for spreading introns throughout the genome, but while Group II introns can splice themselves out ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology ...

The spliceosome and Group II introns are believed to share a common ancestor that was responsible for spreading introns throughout the genome, but while Group II introns can splice themselves out of ...

The Spliceosome Comes Assembled Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, ...