As previously mentioned, the location at which a DNA strand begins to unwind into two separate single strands is known as the origin of replication. As shown in Figure 1, when the double helix ...

More information: Shigeru Matsuda et al, TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA, Communications Biology (2025). DOI: 10.1038/s42003 ...

These findings suggest that TEFM is crucial for the proper regulation of mtDNA replication, particularly at the origin of replication of the heavy strand. In addition, the deletion of TEFM ...