In the early days of President Donald Trump's second term, Alaska Sen. Lisa Murkowski has openly challenged or rebuked him at least three times — stunning for a congressional Republican who has faced his wrath before and yet remains unbowed by pressure to embrace his agenda.

A defining duo of the first Donald Trump administration is back.

Lisa Murkowski, the senior United States senator from Alaska, has held the seat since 2002. When will she be up for re-election? Here's what we know.

Moderate GOP Sen. Lisa Murkowski of Alaska has broken her silence, saying she won't be voting to confirm Pete Hegseth as secretary of defense.

At the White House, President Donald Trump said he was surprised that two senators have publicly said they'll vote against his nominee to lead the Defense Department.

The President's order to rename Denali, North America's highest peak, back to Mount McKinley does not agree with Alaska senator.

Senators Susan Collins and Lisa Murkowski were the only two Republicans who voted against Donald Trump’s choice to head the Department of Defense, Pete Hegseth, in a procedural vote Thursday, citing concerns with his ability to lead the U.S. military.

U.S. Sen Lisa Murkowski was alone in stridently opposing Trump’s blanket pardon for Jan. 6 defendants, and his order to rename Denali as Mount McKinley.

Sen. Lisa Murkowski, considered a key GOP swing vote, said she will not be supporting President Donald Trump's Pentagon pick Pete Hegseth. "After thorough evaluation, I must conclude that I cannot ...

Hours after Pete Hegseth cleared a major procedural hurdle in the Senate, President Trump suggested his embattled nominee may not ultimately be confirmed.

Alaska U.S. Sen. Lisa Murkowski called the nominee an “influencer” and spoke about the importance of vaccines in Alaska.

Trump is speaking publicly so much that he is overwhelming his opponents and leaving them struggling to get a word in edgewise