As previously mentioned, the location at which a DNA strand begins to unwind into two separate single strands is known as the origin of replication. As shown in Figure 1, when the double helix ...

More information: Shigeru Matsuda et al, TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA, Communications Biology (2025). DOI: 10.1038/s42003 ...

Watson and Crick's discovery of DNA structure in 1953 revealed a possible mechanism for DNA replication. So why didn't Meselson and Stahl finally explain this mechanism until 1958 ...

suggesting that the slow replication fork with high origin density may be a hallmark of pluripotency. Surprisingly, forcing an acceleration of replication forks led to miscoordination between ...