Marvel's Fantastic Four is heading for a box office opening north of $100 million as the MCU provides an antidote to universe fatigue.

First Steps hits theaters this weekend, audiences will get a very good look at a very retro spaceship, the Excelsior. But didn't we already see this rocketship before? Haven't the Fantastic Four already crossed over into the main Marvel universe?

The movie, the fifth effort to adapt the comic characters for the big screen, was expected to collect about $220 million worldwide in its first weekend.

This iteration of the Fantastic Four has a standalone adventure without all the burden of the MCU's history and cast of characters.

We're 37 films deep into the Marvel Cinematic Universe. How does "Fantastic Four: First Steps" rank against "Ant-Man" or "Avengers: Endgame"?

First Steps” is the third Marvel movie to hit theaters this year, but it packs way more hidden references and nods than “Captain America: Brave New World” or “Thunderbolts.” It’s not on the same level of Easter eggs as last year’s “Deadpool and Wolverine,

The new “Fantastic Four” blends a retro sensibility with a type of optimism that is reflective of a reboot in the comic book movie industry itself.

Pedro Pascal, Vanessa Kirby, Ebon Moss Bachrach and Joseph Quinn talk to ABC News' Linsey Davis about entering the Marvel Universe, staying true to their characters and the fifth member of the team.