Jamie-Lynn Sigler and Robert Iler, who played siblings Meadow and A.J. Soprano, respectively, face off in PEOPLE's exclusive ...

Jamie-Lynn Sigler was 20 years old when she learned she had multiple sclerosis, but the last two decades have taught her to ...

Christina Applegate and Jamie-Lynn Sigler share painful MS experiences on MesSy podcast, offering support and advice for ...

Christina Applegate is shedding more light on her battle with multiple sclerosis. “For three years, since I was diagnosed, ...

Jamie-Lynn Sigler is reflecting on the scariest time in her life when her 11-year-old son Beau was hospitalized with a life-threatening autoimmune condition last summer. “Those were the hardest ...

Christina Applegate is letting fans in on some of the details of her struggle against MS over the past three years.

Some seven months after her son Beau was hospitalized for 33 days with a rare autoimmune condition, Jamie-Lynn Sigler is now sharing some of the harrowing details of his fight for life.

For three years, since I was diagnosed I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain,” ...

"Kelly, I want to address your throwing up and your diarrhea," the Dead to Me actress said on Tuesday's episode of her MeSsy podcast with Jamie-Lynn Sigler. Applegate began to divulge details of ...

They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else,” the actress ...

Jamie-Lynn Sigler is going up against her Sopranos brother, Robert Iler, on The $100,000 Pyramid! In PEOPLE's exclusive look at the March 23 episode of the game show, the two former costars ...